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When TORCs are forcefully expression in primary muscle cells, it induces its downstream target genes involved in the mitochondrial respiratory chain and TCA cycle, which largely depends on PGC-1

J Mol Biol 195:701729 Berkholz DS, Faber HR, Savvides SN, Karplus PA (2008) Catalytic cycle of human glutathione reductase near 1 resolution

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231 Given the two distinct outcomes of Notch signal transduction, characterizing the properties of Notch signal transduction, including its broad functional roles, dependence on upstream and downstream signaling factors, precise spatiotemporal specificity, and crosstalk with other pathways, is essential